The focus of High Performance Distributed Systems Laboratory (HPDSL) is to design, develop, and evaluate the next-generation of extremely parallel and scalable distributed systems with the focus on achieving high-performance. Specifically, we focus on building system software and middleware stacks that hide the underlying resource and performance heterogeneity in modern datacenters, and provides efficient utilization of the available resources in the shared, e.g., cloud, and dedicated, e.g., high-performance computing (HPC) environments. Our innovations enable improved performance, resilience, and scalability of distributed frameworks, and lower the barriers of using them in large scale settings.