Let $F \to E \to B$ be a fibration with $B$ simply connected (more generally, such that $\pi_1(B)$ acts trivially on the homology of $F$). Then there is a Serre spectral sequence $H_p(B, H_q(F)) \to H_{p+q}(E)$. One can do the same for singular cohomology. However, for reasonable spaces (specifically, locally contractible spaces, e.g. CW complexes), singular cohomology is the same as sheaf cohomology of the constant sheaf $\mathbb{Z}$.
But there is another spectral sequence for sheaf cohomology: the Leray spectral sequence. Given spaces $X, Y$ and $f: X \to Y$, and a sheaf $\mathcal{F}$ on $X$, there is a spectral sequence $H^p(Y, R^q_f(\mathcal{F})) \to H^{p+q}(X, \mathcal{F})$. The Wikipedia article hints that the topological implications of this include in particular the Serre spectral sequence. I would be interested in this, because I like the machinery of the Grothendieck spectral sequence (from which the Leray spectral sequence easily follows), and would be curious if the Serre spectral sequence could be obtained as a corollary.
Is this possible?