The answer depends on what you mean by "solving" the PDE. The initial value problem for the ultrahyperbolic PDEs are ill-posed. In particular, there is a theorem (the version I know is due to Hormander, you can find it in his Analysis of Linear Partial Differential Operators; but presumably some versions go back earlier) which states that:
Theorem Let $L$ be a linear partial differential operator with smooth coefficients of order $m$ on $\mathbb{R}^{1+n}$. Consider the Cauchy problem for $Lu = F$ on the upper-half-space $\{ x_0 \geq 0 \}$ with initial data $u_0, u_1, \ldots, u_{m-1}$ (such that $(\partial_0)^k u|_{x_0 = 0} = u_k$ ). Then the following are equivalent. (a) The Cauchy problem has a unique smooth solution $u$ for every prescribed smooth data $u_0,\ldots,u_{m-1}$ and source $F$ and (b) $L$ is a hyperbolic operator.
So in particular, in general there cannot be well-defined solutions to the initial value problem for ultrahyperbolic PDEs. (They either don't exist or aren't unique. And in the case you do have a solution, the solution is unstable.)
Now, you cannot even construct approximate solutions to the initial value problem reliably using numerical methods, since ultrahyperbolic equations do not have finite-speed of propagation, so you cannot "localise" the problem, and small changes around a point $x$ may almost instantaneously affect the solution at a far-away point $y$.
In certain special cases you can produce some semblance of a solution. In the constant coefficient case in second order, where the equation can be written as $(\triangle_X - \triangle_Y)u = 0$, you have what is known as Asgeirsson's Mean Value Theorem which is sort of a generalisation of the mean value theorem for harmonic functions, and also a generalisation for the Green's function formula for the linear, constant coefficient wave equation. In this particular case you can also consider solutions using Fourier analytic methods. From there one sees that if one were to assume certain restrictions on the allowed wave-numbers (which leads to a non-local constraint on the initial data), one can recover well-posedness of the initial value problem.
As to references, perhaps an easy way to do a reverse search on the classical paper of Fritz John on the subject. John's various textbooks also contain some information about it; in particular you may want to consult his Partial Differential Equations book, and his book on Plane Waves and Spherical Means Applied to Partial Differential Equations.