You can use the technique of Vacant Spaces to calculate probabilities.
During play, if you know that there is space for $\displaystyle x$ unknown cards with West and $\displaystyle y$ unknown cards with East, the probability that a specific card is with west is $\displaystyle x/(x+y)$. This assumes you ignore the carding of the opponents so far. This gives accurate results when computing the apriori probabilities and gives reasonable values during the play of the hand.
So, say you want to calculate the apriori probability of a 3-2 split.
First consider a specific holding say (Q32 with West and 54 with East) and try to calculate the chances.
Chances that West gets the Q = 13/26.
Chances that West gets the 3 = 12/25.
Chances that West gets the 2 = 11/24.
Chances that East gets the 5 = 13/23.
Chances that East gets the 4 = 12/22.
Thus the chances of the specific split Q32-54 is
$13/26 \times 12/25 \times 11/24 \times 13/23 \times 12/22$
There are 5 choose 3 + 5 choose 2 = 20 such splits.
Thus the probability of 3-2 split is 20 times
$13/26 \times 12/25 \times 11/24 \times 13/23 \times 12/22$
$= 0.678\dots$
Thus there is a 67.8% chance of a 3-2 break.
A good rule of thumb to remember is that if there are an odd number of cards outstanding, then apriori chances are that they will split as evenly as possible. So with 5 cards outstanding, 3-2 is split is more likely than 4-1 or 5-0.
If there are an even number of cards outstanding, then they tend to break unevenly.
There are exceptions though: with 2 cards outstanding, 2-0 split is less likely than 1-1.
See:
An article on Vacant Spaces: http://www.clairebridge.com/textes/vacantplaces.pdf
Pavlicek's Suit Break Calculator: http://www.rpbridge.net/xsb2.htm